Gentrisone ointment is the pharmaceutical of Shinpoong Pharmaceutical Co., Ltd. – Vietnam. The drug is used to treat corticosteroid-responsive skin allergies and dermatitis such as eczema, seborrheic dermatitis, contact dermatitis, psoriasis, … In addition, this drug is also used in treating infections. skin surface caused by susceptible bacteria and some fungal skin diseases.
Table of Contents
What is Gentrisone medicine?
Gentrisone is a topical medication of Shinpoong Pharmaceutical Co., Ltd. – Vietnam. The drug is used to common acute – chronic dermatological diseases that respond to corticosteroids. In addition, the drug is also used in the treatment of skin surface infections caused by bacteria or yeast.
This is one of the most commonly used medications for dermatological diseases. It is available at most private pharmacies nationwide and can be used without a prescription.
Some information to know about Gentrisone topical drugs:
- Drug name: Gentrisone
- Category: Medicines for the treatment of dermatological diseases
- Ingredients: Betamethasone, Clotrimazol and Gentamicin
- Dosage form: Topical cream
- Specification: 10g and 20g tubes
- Manufacturer: Pharmaceutical Co., Ltd. Shinpoong Daewoo
Ingredients of skin cream Gentrisone
The main ingredients of the skin ointment Gentrisone:
- Betamethasone dipropionate (6.4mg and 12.8mg, respectively, 10g and 20g tubes): Betamethasone is a synthetic corticosteroid with anti-itch and anti-inflammatory effects. This active ingredient has the potential to absorb through the skin – especially when applied to open skin or under a bandage after application.
- Clotrimazol (100mg and 200mg, respectively, 10g and 20g tubes): Clotrimazol is a derivative of imidazole that is effective against yeasts, fungi and skin fungi by inhibiting the synthesis of ergosterol causing the cell membranes of fungi to weaken. in terms of structure and function. As a result, the fungus is unable to continue to divide and grow. Clotrimazol can be absorbed through the skin, but its concentration is negligible and causes almost no systemic symptoms.
- Gentamicin (10mg and 20mg respectively with 10g and 20g tubes): Gentamicin is an antibiotic active in the aminoglycoside group. This active ingredient has a broad antibacterial spectrum, sensitive to both gram-negative and gram-positive bacteria. Gentamicin is absorbable through the skin and can cause systemic symptoms – especially when applied to areas with wounds, burns, and flakes.
In addition, the drug also contains some excipients such as methyl paraben, light mineral oil, propyl paraben, purified water, cetanol, propylene plycol, stearyl alcohol, …
What does Gentrisone topical do?
Topical Gentrisone contains anti-inflammatory – anti-allergic, antifungal and antibacterial active ingredients. Therefore, the drug is used to treat many common dermatological diseases such as:
- The drug works to reduce itchiness and improve the inflammation of skin inflammatory and allergic skin diseases that respond to corticosteroids such as urticaria, squamous dermatitis, acute – chronic eczema, psoriasis, seborrheic dermatitis, atopic dermatitis, contact dermatitis , …
- It also helps relieve itching and red inflammation caused by minor burns, insect stings, and itching of the vulva and anus
- Treatment of skin surface infections caused by bacteria sensitive to Gentamicin and Clotrimazol
- Treatment of dermatological diseases caused by the fungus Malassezia furfur, Candida albicans, Epidermophyton floccosum, … such as stem fungus (ringworm, squash), tinea versicolor, foot fungus and some skin lesions caused by susceptible strains
Contraindicated
Do not use topical Gentrisone in the following cases:
- Skin ulcers and burns of degree 2 or higher (due to increased absorption of active ingredients in the drug and can cause systemic reactions)
- Illness (a dermatological disease that starts in late winter and early spring and manifests itself as purple or red patches of skin or soft nodules due to a reaction to cold)
- Eczematous dermatitis of the outer ear canal accompanied by a perforation of the eardrum
- Skin tuberculosis, syphilis, cowpox, herpes zoster and herpes simplex
- Hypersensitivity to antibiotics belonging to the aminoglycoside group such as Neomycin, Gentamicin, Kanamycin, Streptomycin, …) or to any ingredient in the drug
Instructions for the use of the drug Gentrisone to treat eczema
The drug Gentrisone is applied directly to the area of the skin that needs treatment.
User manual:
- Clean hands with soap, dry and clean the area to be treated with saline
- Use a sufficient amount of cream to apply on the skin to be treated
- Wait for the cream to absorb and dry completely before dressing
- Absolutely do not cover the skin – especially on open skin because it can increase the absorption of the drug and cause systemic symptoms
- Use 1 or several times a day
After using the medicine, you should clean your hands with soap and dry them (except when treating the skin on your hands) to avoid getting the medicine in your eyes and mouth. Although it is topical, Gentrisone has the ability to absorb and cause a systemic reaction. Therefore, it is important to follow the instructions of your doctor or use as recommended by the manufacturer.
Note when using topical medicine Gentrisone for vitiligo, fungal skin
The drug Gentrisone is used to treat many dermatological diseases such as eczema, seborrheic dermatitis, vitiligo, ringworm, and surface infections caused by susceptible bacteria, … if used improperly or overused.
1. Caution
Gentrisone is a treatment, not a support product. Therefore, you should talk to your doctor / pharmacist and read the instructions carefully before taking it.
In the case of acute and chronic dermatitis with superinfection of fungi or bacteria, it should be used in combination with antifungal or oral antibiotics. Using Gentrisone alone can increase the risk of resistance and make the infection worse.
Active ingredients Gentamicin and Betamethason in the drug have the ability to absorb through the skin and cause a systemic reaction. Therefore, except in the case of a prescription from a doctor, avoid using the drug on a large scale, covering the area of the applied skin and using it for a long time. Long-term use of Gentrisone may cause local or systemic toxicity (cataracts, Cushing’s syndrome).
The degree of absorption of the drug is significantly increased when used in thin areas such as the face and skin folds. In this case, the drug should be used only for a short time and for a maximum of 5 days for children.
Limit use of the drug in the diaper area because it can have an effect similar to a bandage, leading to increased absorption of the drug into the body and inhibition of the adrenal glands. Furthermore, children’s skin is thin and sensitive so it has a higher absorption capacity than adult skin. So to ensure safety, only use the drug for children when consulting a doctor.
When treating psoriasis , the drug Gentrisone and topical corticosteroids can cause an adverse reaction leading to systemic toxicity, development of purulent psoriasis and impaired skin resistance function.
There are insufficient studies on the benefits and risks of the drug in pregnant and lactating women. Therefore, use the drug only when directed by a specialist. In addition, care should be taken when using drugs for people with kidney failure, stomach ulcers, liver failure, psychosis, osteoporosis, hypothyroidism, epilepsy, myocardial infarction, congestive heart failure. , diabetes, cataracts, glaucoma, …
2. Unwanted effects
The drug Gentrisone can cause some side effects when it is used. The frequency and severity of adverse events depend on the dose, the extent of the skin to be treated, and the frequency and duration of drug administration.
Common side effects:
- Bacterial and fungal infections caused by corticosteroids suppress the skin’s immunity
- Rash, irritation (should be discontinued)
Uncommon side effects:
- Using the drug for a long time, covering the medicated area or using the medicine on a large area of the skin can cause some side effects (mainly from Betamethasone) such as swelling, acne , blisters, thinning of the skin. , atrophy of the epidermis, …
- High drug concentration can cause systemic symptoms such as Cushing’s syndrome, adrenal suppression, sodium and water retention, loss of potassium, menstrual disturbances, muscle weakness, loss of muscle mass, and thymus inhibits fetal growth in the uterus, osteoporosis and aseptic abscess formation.
Inform your specialist about undesirable effects encountered while using the drug.
3. Drug Interactions
There are no studies on drug interactions for topical use. However, when absorbed into the bloodstream, the active ingredients in the drug Gentrisone can interact with:
Betamethasone:
- Paracetamol: Increases liver toxicity and liver toxicity
- Insulin and diabetes medications (oral form): Can increase the effectiveness of hypoglycemia, so it is necessary to adjust the dose if used in combination.
- Tricyclic antidepressants: This group of drugs increases psychosis caused by Betamethasone and other corticosteroids.
- Glycoside digitalis: Concomitant use with the drug Gentrisone can cause arrhythmias, increase the toxicity of digitalis and lower the concentration of potassium in the blood.
- Ephedin, Rifampicin, Phenytoin and Phenobarbital: The effectiveness of these drugs may decrease when used with Betamethasone, and increase the metabolism of Betamethasone and other corticosteroids.
- Alcohol and nonsteroidal anti-inflammatory drugs: Increases side effects on the esophagus, duodenum, and stomach and increases the risk of gastrointestinal bleeding.
- Estrogen: Estrogen reduces the rate of Betamethasone elimination, leading to increased therapeutic effects and increased toxicity to the body.
- Coumarin: Betamethason increases or decreases the anticoagulant effects of this drug.
Clotrimazol:
- Tacrolimus: Simultaneous use to increase the concentration of Tacrolimus – especially in patients performing liver transplantation. Therefore, in case of need, the doctor will reduce the dosage to ensure safety.
4. Overdose and treatment
Gentrisone overdose occurs only when swallowed. In this case, it is necessary to immediately go to the hospital for prompt treatment. Treatment of Gentrisone overdose is mainly about symptom control and the application of supportive measures.
However, if there are obvious symptoms such as vomiting, nausea, and dizziness, the doctor will perform gastric lavage to reduce the level of drug absorption.
Is Gentrisone good? How much?
Gentrisone is a treatment for common dermatological diseases such as skin surface infections caused by susceptible bacteria, inguinal fungus, ringworm, vitiligo, acute – chronic eczema, seborrheic dermatitis, urticaria, urticaria. due to insect bites, … With the formula combining anti-inflammatory – anti-allergic, antifungal and antibiotic properties, the drug is able to inhibit skin damaging agents, reduce inflammation, itching and improve some symptoms accompany.
As a therapeutic drug, Gentrisone has a relatively homogeneous effect and almost does not depend on the site as the support products. However, the drug is used only in cases of minor burns and minor injuries. If the skin burns from degree 2 onwards, the lesion is wide and is superinfected with fungi and bacteria, talk to your doctor for other medications.
Gentrisone skin cream is priced at 25,000 VND / 10g tube and 40,000 VND / 20g tube. Currently, the drug is available in most private pharmacies nationwide.
Some questions related to the skin drug Gentrisone
1. Can Gentrisone drug be used for pregnant women, lactating women?
Currently there are not enough data to prove that the drug is safe for pregnant women and those who are breastfeeding. Therefore, if you intend to use the drug, you should consult your doctor for specific advice.
2. Can Gentrisone be used for babies?
The drug Gentrisone can be used to treat infant eczema . However, the drug can be absorbed through the skin and cause a systemic reaction. Therefore, parents should only use it for children when consulting a doctor and need to use the correct dosage and time indicated to limit side effects and risk situations.
3. Can Gentrisone be applied to the genital area?
Some dermatological conditions, like eczema and groin fungus, can develop in the genital area. According to information from the manufacturer, the drug Gentrisone can be used for the anal area, vulva but not for use in the vagina. Therefore, you can use the drug for the genital area but need medical advice before use.
4. Can Gentrisone cure acne?
In fact, the active ingredients in the drug Gentrisone have the ability to treat acne. In it, Betamethason helps reduce inflammation and anti-itch. Clotrimazol and Gentamicin have the effect of inhibiting harmful yeast and the gram-positive bacteria P. acnes (the cause of acne).
However, the drug Gentrisone is not recommended for acne treatment because it can cause many side effects and risky situations. Therefore, you should use a specialized acne cream to improve the skin condition.
This article has compiled basic information about the topical medicine Gentrisone for eczema, ringworm and ringworm. If you intend to use the drug, please read the instructions carefully or consult your pharmacist / doctor before taking it.
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Tốt nghiệp hệ Bác sĩ đa khoa, Trường Đại học Y Hà Nội (2011)
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