Use of gout medications is one of the most commonly prescribed methods of pain relief and gout treatment. Currently, there are many medicines to treat gout, so patients should carefully study and choose the most suitable medicine, because not all drugs are effective and even cause side effects.
Gout is a disease that manifests itself as a condition of arthritis . It occurs due to uric acid metabolism disorders, thereby increasing the concentration of uric acid in the blood to deposit urate crystals in the joints and consequently cause pain. Normally, the concentration of uric acid in the blood is said to be stable in the range of 2 – 5mg / 100ml, while those with gout this index is up to 8.8mg / 100ml.
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The need to use drugs to treat gout
According to the experts, gout is one of the common malignant osteoarthritis diseases today. Its destructive power is extremely large and heavy to the skeletal system, mildly painful, difficult to walk, and if severe, it can cause paralysis, even death if not detected. treatment promptly.
However, at present, there are still many people who are subjective in the treatment of gout, even without the most general understanding of the disease, it is understandable that the disease is getting worse and worse.
According to experts, the nature of gout is a form of arthritis that occurs due to many different causes such as high levels of uric acid in the blood, disorders of purines in the blood … All of these are derived from habits. eating habits, unscientific activities, drinking a lot of alcohol, eating too much red meats, animal organs.
To treat the disease in a timely manner, without causing serious consequences, the patient needs to actively examine and use gout medicines from an early stage. The earlier use of the drug will help reduce the symptoms of swelling, redness, pain, inflammation, and avoid complications such as polio and death.
Therefore, the demand for gout medicines is increasing. Because it is the most effective, simple and fastest effective therapy for disease control.
What groups of gout medicines are there?
In fact, the treatment of gout is mainly aimed at suppressing inflammation and controlling pain, lowering the uric acid level in the blood at the moment of an acute gout attack. Only when using the medicine correctly as prescribed by the doctor and changing the living habits and eating science can it be completely cured.
Currently, gout medicines are divided into 3 main groups, including:
The group of drugs that reduce uric acid synthesis
- Allopurinol : This is a drug that inhibits the XO enzyme (Xanthine Oxidase) and converts it to oxypurinol for renal excretion. The drug is indicated for use to reduce uric acid levels in gout and kidney stones.
- Febuxostat : This is a non-purine selective XO. This drug is indicated for use in patients allergic to Allopurinol. The drug works to reduce the concentration of uric acid in gout effectively.
- Topiroxostat : This is a selective and non-purine XO inhibitor, effectively helping to reduce uric acid in the blood.
The group of drugs that increase uric acid excretion
The introduction of drugs that increase uric acid excretion to aid uric acid lowering is essential in the case of ineffective XO enzyme inhibitors to reduce uric acid synthesis.
Some drugs of this group may be mentioned as: probenecid, benzbromarone, lesinurad …
The group of drugs that destroy urate
This group of drugs has the effect of rapidly and immediately lowering uric acid levels by converting uric acid into water-soluble allatonin and excreted by the kidneys. However, due to the rapid lowering of uric acid, the drug can cause side effects that are faster recurrence of gout attacks and drug resistance after several months of treatment.
Pegloticase and Rasburicase are two common types in this group of drugs.
In addition, there are a number of drugs that are indicated for the relief of common gout attacks such as: Colchicine, Corticosteroids, and NSAIDs.
Top 10 popular gout support and treatment drugs
Allopurinol gout medicine
This is the drug most commonly used to treat chronic gout. The main ingredient is Allopurinol, which inhibits the production of uric acid both in the blood and urine, thereby reducing the deposition of urate in the kidneys and joints, thereby preventing the development of gout. .
The advantage of this drug is that it can be used for a long time to maintain a constant uric acid concentration and prevent the risk of recurrence of acute gout attacks and complications of gout.
Indications for use:
- Allopurinol is indicated for use in patients who have experienced acute attacks of gout.
- Can be taken with Colchicine or nonsteroidal anti-inflammatory drugs to reduce uric acid levels.
Dosage:
- Initial dose: 1 tablet per day with a dose of 100mg / day
- Maintenance dose: increase dose to 200-300mg / day in mild form and 400-600mg / day if the disease is severe.
Side effects:
The process of using Allopurinol can occur some unwanted side effects such as:
- Rash, itchy red spots
- Nausea, vomiting
- Headache
- Stomachache
- Diarrhea
- Asleep
* Note: Tell your doctor right away if symptoms tend to be serious and dangerous to be promptly overcome.
Reference price: Currently, Allopurinol is sold on the market with the price from 40,000 to 50,000 VND / box of 30 tablets of 300mg.
Colchicine gout medication
Colchicine is one of the drugs of choice for the treatment of gout today thanks to its strong anti-inflammatory properties and rapid pain relief. With the ability to inhibit the migration of neutrophils in the inflamed joint area, thereby reducing the inflammatory response to urate crystals and bringing the optimal therapeutic effect.
The drug is available in the form of tablets for oral administration and in the form of a solution for intravenous administration. However, if used incorrectly, Colchicine poisoning is very dangerous.
Indications for use:
- Colchicine is used in combination with allopurinol to support pain relief, anti-inflammatory in acute gout attacks.
- Combined with non-streroid anti-inflammatory analgesic drugs to increase effectiveness in relieving gout attacks.
- Support to prevent recurrence of gout.
Dosage:
Colchicine dose is recommended as soon as possible from the onset of gout.
- The first day: Take a dose of 1mg / time, take 3 times a day, each time is about 2 hours apart, the maximum day should not exceed 4mg.
- Day 2: Use 1mg / day, 2 times a day.
- Day 3 onwards: Use 1mg / time, use for about 6 months as directed by your doctor. Note to increase or decrease the dosage to suit the elderly, people with chronic kidney disease …
Note there is no dose for children under 18 years old
Side effects:
Long-term use of Colchicine may cause a number of side effects such as:
- Drug poisoning because using high doses causes hair loss, anemia.
- Abdominal pain, diarrhea
- Nausea, vomiting
- A rash
- Damage to the liver, kidneys
- Peripheral neuritis
- Gastrointestinal bleeding
For children, Colchicine is extremely poisonous, if accidentally ingested 1-2 tablets will cause serious poisoning.
* Note: Tell your doctor right away if symptoms tend to be serious and dangerous to be promptly overcome.
Reference price : Colchicine price on the market today ranges from 110,000 – 120,000 VND / box.
Medication for gout Febuxostat
Gout treatment Febuxostat is a drug imported from Uloric Cave, USA. The drug contains the main ingredient Febuxostat and has the same effect as Allopurinol reduces the concentration of uric acid in the blood and can be used for a long time to treat gout. Therefore, the drug is very suitable for people with gout allergic to allopurinol.
The drug is available in the form of tablets for oral administration. The product is highly appreciated by experts than the standard dose of Allopurinol. Therefore, Febuxostat is being used widely and selected by many patients.
Indications for use:
- The drug is indicated for use in patients on treatment of chronic hyperuricemia when urate deposition has occurred. Or the cases have appeared tophi and arthritis.
- Not recommended for use to treat asymptomatic hyperuricemia.
Dosage:
- Initial dose: 40mg / day, once a day.
- Can increase 80mg / day, once daily in patients who do not achieve serum irat index below at 6mg / dL after 2 weeks of treatment with a dose of 40mg / day.
- If uric acid concentration> 6mg / dL after 2-4 weeks of treatment with a dose of 80mg / day, the dose may be considered to increase to 120mg / day.
- In the elderly, people with mild renal impairment or mild liver failure can use the above dose without adjustment.
- Standard dose of Febuxostat is recommended for at least 6 months to prevent recurrence of gout attacks.
- During the use of Febuxostat, note that it is not allowed to add any antibiotics, especially Allopurinol.
- Child dosage: There is no dose for children under 18 years old
Side effects:
Long-term use of Febuxostat may cause a number of side effects such as:
- Nausea
- Rashes on
- Headache, dizziness, dizziness
- Joint pain or stiffness
- The urine is dark, the stools are clay-yellow
- Stomachache
- Anorexia
* Note: Tell your doctor right away if symptoms tend to be serious and dangerous to be promptly overcome.
Reference price : The current Febuxostat price on the market fluctuates at many prices depending on the manufacturer, domestic or foreign medicine:
- Feburic gout 80mg (Japan), box of 30 tablets: price of 27,300 VND / tablet, box of 30 tablets of 811,000 VND.
- Feburic 80mg (Thailand) box of 30 capsules: price 25,725 VND / tablet, box of 3 blisters x 10 tablets.
- Friburine 40mg (Vietnam): price 14,000 VND / tablet.
- Febustad 40mg (Vietnam): price 15,000 VND / tablet.
Medicines to treat gout Lesinurad
Lesinurad is a drug that supports the treatment of gout and is trusted by many patients. The new drug was approved for use in the treatment of gout since December 2015. With the dosage form of tablets, tablets belong to the group of non-steroidal anti-inflammatory drugs that are effective in treating gout and bone and joint diseases.
Lesinurad drugs are often combined with allopurinol and work on the principle of treatment to remove excess uric acid in the blood and inhibit the deposition of urate in the joints.
Indications for use: The drug is often indicated for use in cases where the standard dose of Allopurinol is not effective enough to overcome symptoms of gout.
Dosage:
- The recommended daily dose is Allopurinol 300mg – Lesinurad 200mg and Allopurinol 200mg – Lesinurad 200mg. Drink 1 time per day.
- The best time to drink is every morning after breakfast.
- Lesinurad is not recommended for patients with creatinine clearance less than 60 mL / min and are using Allopurinol at doses below 300mg or below 200mg ..
- It is recommended to take the pill with 8 ounces of water to help prevent the risk of kidney stones.
Side effects:
Using the drug Lesinurad can cause a number of side effects such as;
- Stomach pain, nausea, vomiting, diarrhea
- Asleep
- Numbness in hands and feet
- Anorexia, unusual weight loss
- Fever and frequent chills
- Persistent sore throat
- Rash
* Note: Tell your doctor right away if symptoms tend to be serious and dangerous to be promptly overcome.
Reference price: Currently, the price of a bottle of Lesinurad 30 pills is about 9,000,000 VND. Because drug prices are too high compared to the economy of most patients, there are still very few people who choose to use although the treatment effect is very good.
Probenecid gout medicine
Probenecid is a medicine used to prevent gout and acute gout arthritis. The drug is prepared in the form of tablets belonging to the Uricosuric group, which helps the kidneys to eliminate and reduce uric acid from the body. From there, achieve more effective gout treatment.
Probenecid has no analgesic effect, so it is usually prescribed by a doctor to combine with colchicine, ibuprofen or indomethacin for more effective pain relief.
Indications for use: The drug is often indicated for use in cases of gout patients with increased uric acid in the blood, symptoms of chronic arthritis and tophi.
Dosage:
- For adults: Initial dose 250mg / time, 2 times a day for 1 week; Maintenance dose 500mg / time, 2 times a day; Consider increasing the dose by 50mg until stabilization of the concentration of uric acid in the blood.
- For children: Initial dose 25mg / kg / day, only one dose; Maintenance dose 10mg / kg / day. Do not use Probenecid for children under 2 years old.
Side effects:
Some of the side effects that may occur during the use of Probenecid include;
- Nausea
- Dizziness
- Anorexia
- Headache
- Gum pain
- Urinating many times, the urine is strange color.
* Note: Tell your doctor right away if symptoms tend to be serious and dangerous to be promptly overcome.
Reference price:
Oral support pills for the treatment of gout Uric Acid Complex
This is the famous gout medicine from the brand Botanics Choice. The product is prepared in the form of an oral tablet with a combination of ingredients including: Microcrystalline Cellulose, Silicon Dioxide, Gelatin, Magnesium Stearate and some other natural extracts.
Currently, Uric Acid Complex gout support pill is not only sold in the US but also popular in many countries around the world, including Vietnam.
Products’ use:
Uric Acid Complex oral tablet brings some of the following effects;
- Quickly cut pain, swelling, inflammation in the injured joints caused by acute or chronic gout attacks.
- Improve the functioning of the degenerated skeletal system, replenish the natural nutrients to help the body stay flexible and flexible.
- Prevention of dangerous complications of knee osteoarthritis due to gout such as paralysis, bone cancer, …
- Promote metabolism and metabolism of substances in the body, inhibit the production of uric acid levels in the blood.
- Improves the function of dialysis, diuretic and slows down the aging process in middle age.
- Preventing the risk of stroke, improving health, improving mental health and helping the patient eat and sleep well.
User manual:
- Take 2 capsules / time, take only once a day.
- The best time to take the medicine is during or immediately after a meal.
Contraindications to use:
- Do not use for children under 12 years old.
- Pregnant and lactating women
- Patients who are taking other prescription medications or supplements
- These are sensitive and allergic to any ingredient of the drug.
Reference price: Uric Acid Complex oral capsule is currently being sold on the market for 955,000 VND / box of 60 soft capsules.
Anserine minamin gout oral treatment
Oral Anserine minamin is one of the products that support the treatment of gout effectively thanks to its ability to inhibit the formation of uric acid. The drug is prepared in the form of tablets for oral use and has been licensed by the Japanese Ministry of Health for circulation both at home and abroad.
The product is a combination of the main ingredients including: Anserine, Lactose, Western bark extract, Lactose, Sucrose ester …
Products’ use:
Oral Anserine minamin brings many health benefits of patients such as:
- Quick relief from sudden recurrence of pain caused by acute and chronic gout attacks.
- Improve kidney function to actively remove uric acid from the body.
- Assists in the recovery of motor function of joints damaged by gout.
- Inhibits urate formation and deposition in the joints and reduces the concentration of uric acid in the blood.
- Reduced ability to metabolize as well as absorb protein from foods in the blood.
- Provide essential nutrients to help prevent the aging process, enhance heart health, improve overall health for patients.
User manual
- Take 10 capsules a day, divided into 2 doses.
- Drink immediately after each meal for the best effect.
Reference price: Currently, genuine Anserine minamin gout oral tablet originating from Japan is priced at 750,000 VND / box including 240 tablets.
Tart Cherry Amazing Formulas gout treatment medicine
This is one of the oral tablets originating from the United States and has the effect of supporting the treatment of gout with pure sour cherry extract very effectively and safely. Regular use of the drug will help significantly reduce pain and swelling in the joints due to the high content of antioxidants.
Products’ use:
- With powerful antioxidant properties, it will help prevent clogging of blood vessels, no longer cause deposition of urate crystals in joints.
- Helps to reduce the concentration of uric acid in the blood effectively.
- Stabilize blood pressure, control fat in the blood effectively.
- Prevent gout recurrence for people who regularly drink a lot of alcohol and eat a lot of protein.
User manual:
- Adults: 1-2 capsules a day
- Contraindicated for use in children under 12 years old.
- Should use the drug immediately after each meal for the best effect
Reference price: Tart Cherry Amazing Formulas gout treatment drug currently is sold a lot on the market and has genuine price is 490,000 VND / box of 50 tablets.
Oral support for the treatment of gout GoutClear
GoutClear oral tablet is a gout treatment support product widely used in the US and other countries around the world, including Vietnam. The product is prepared in the form of a tablet with main ingredients including Folic acid, art cherry extract combined with Garlic extract, Rutin and Turmeric root …
Products’ use:
- Improved uric acid reduction in the blood of people who drink a lot of alcohol regularly.
- Enhance the function of kidney uric acid elimination activity.
- Support to overcome symptoms of swelling, pain, swelling in the joints caused by gout.
- Supplementing nutrients that work to improve the skeletal system, help bones strong, supple and restore function.
- Prevent recurrence of symptoms and pain caused by gout.
Indications / Contraindications to use:
- People with gout have symptoms of pain, swelling, and inflammation in the joints.
- People with high levels of uric acid in the blood.
- Preventive use for people who regularly drink alcohol.
- Do not use the drug for children, pregnant and lactating women.
- People allergic to any ingredient of the drug.
User manual:
- Take 2 times a day, 1 capsule each time after any meal.
- Drink plenty of water in each drink to increase the elimination of side effects.
Reference price : The price of a pill box of GoutClear 60 pills ranges from 1,000,000 to 1,200,000 VND.
Medicines to treat disease GoutPro Uric Acid Cleanse Inflammation Supplement
This is a drug originating from the US but is known by many people and popularly used in many countries. The drug is prepared in the form of capsules and includes the main ingredients: Proprietary Blend 500mg, Yucca Root Powder, Aged Garlic Powder, Artichoke Powder, Milk Thistle Extract (80% Silymarin), Curcumin (Turmeric) Powder.
Products’ use
- The drug works to prevent and support relief of joint pain, reduce inflammation in the hand and foot gout sockets quickly.
- Maintain stable concentration of uric acid in blood
- Prevent edema, water retention in the body.
- Inhibits the crystallization and deposition of urate crystals in the joints and organs in the body.
- Supplement essential nutrients to help strengthen the immune system, protect and support the functioning of the kidneys.
User manual
- Drink 2 times a day, 1 tablet each time
- It is best to drink immediately after eating for best results.
Reference price : The price of GoutPro Uric Acid Cleanse Inflammation Supplement drug on the market is about 1,500,000 VND / box of 60 tablets.
Some notes when using drugs to treat gout
According to experts, gout is a disease classified in the group of chronic diseases that have no complete cure. The use of gout medicines is aimed at controlling symptoms of the disease, while preventing risk factors that cause gout, and preserving the functioning of the joints.
Therefore, in order to achieve the best results in the process of using drugs to treat gout, patients should note the following things:
- Absolutely follow the dosage of the doctor prescribed for special medicines and follow the instructions for use printed on the package for drugs that support treatment.
- The drug can cause side effects during use, so pay attention and consult your doctor to fix it as soon as possible.
- All gout medicines will not work if the patient does not have a low-protein diet, stay away from alcohol …
- Increase drinking water after each pill to increase uric acid elimination and reduce side effects of the drug.
- Choose to buy drugs at reputable and quality Western pharmacies, especially for imported drugs, avoid buying drugs at places that sell too cheaply to avoid losing money.
Hopefully, with the information in the above article, it will help the patient to have more basic information about the medicines capable of treating gout. However, the use of drugs should comply with the prescription of the doctor, not arbitrarily buying or increasing or decreasing the dose to avoid affecting the treatment results.
